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efficacy/potency
Efficacy and potency studies are crucial in preclinical drug development, ensuring that potential therapeutics demonstrate the desired biological activity at appropriate concentrations.
In preclinical drug development, evaluating the efficacy and potency of a new compound is essential for determining its therapeutic potential. Efficacy refers to the maximum biological effect a drug can produce, while potency measures the concentration or dose required to achieve that effect. Together, these parameters provide critical insights into a drug candidate’s pharmacological profile, guiding decisions on further development.
Parameters that are typically evaluated include:
• Effective Concentration (EC50)
• Effective Dose (ED50)
• Therapeutic Index (TI)
• Clinical Chemistry and Hematology, including evaluation of markers reflecting stress or disease state.
Depending on the qualities of your compound and the drug target, Truly Labs can offer a variety of in vitro and in vivo models to best suit your needs.
New drug candidates are often benchmarked against existing treatments to evaluate relative efficacy and potency. A compound that demonstrates superior activity at lower concentrations can offer advantages such as reduced side effects and improved patient compliance. Efficacy and potency studies help refine dosing strategies, optimize therapeutic outcomes, and minimize the risk of failure in clinical trials.es, and minimize the risk of failure in clinical trials.
