Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.
Imaging
Live imaging, both in vitro and in vivo, provides a powerful and comprehensive approach to understanding drug efficacy and safety, offering real-time insights essential for preclinical drug development.
Live cell imaging technology enables continuous, real-time monitoring of compound effects on cell health, proliferation, and function in vitro. Specifically, it provides detailed insights into cellular processes such as apoptosis, cytotoxicity, protein and antibody binding and internalization, as well as immune cell-mediated killing, offering a deeper understanding of mode of action, while adhering to 3R principles.
We offer the Incucyte® automated microscopy platform, which captures images dynamically over hours, days, or even weeks, providing comprehensive insights into long-term cellular responses for drug evaluation and screening.
Alternatively, we offer the Revolution, an automated microscope imaging system, which enables live cell imaging under hypoxic conditions, effectively mimicking the low-oxygen tumor microenvironment to enhance the prediction of drug responses in cancer models.
Further, we can perform in vivo live imaging using optical imaging, and additionally offer CT, MRI, and PET, all of which can be integrated into preclinical studies to monitor drug interactions, biodistribution, and therapeutic effects. Optical imaging enables detailed visualization of molecular targets, while CT and MRI provide high-resolution structural insights, helping to assess organ-specific drug distribution. PET imaging further enhances these capabilities by enabling the tracking of metabolic activity and drug targeting at the cellular level.
The technologies we offer allow evaluation of how drugs behave within living organisms in real time, improving understanding of tissue penetration, metabolism, and off-target effects. By incorporating these imaging modalities into preclinical research, dosing strategies can be refined, treatment regimens optimized, and biomarkers assessed with higher accuracy. Besides live imaging, we can also provide high-throughput immunofluorescence imaging of fixed samples, enabling precise protein localization or even protein interaction analysis using PLA technology (proximity ligation assay). This approach offers valuable insights into drug mechanisms while supporting efficient drug screening.
