flow cytometry

Accelerating Drug Development with Cutting-Edge Cell Analysis

Multi-parameter flow cytometry is a powerful tool providing critical data on biomarker expression, cell signalling and toxicity, to optimize drug candidates and reduce late-stage failures.

Flow cytometry allows for detailed analysis of millions of cells in minutes, giving detailed information on both extra- and intracellular biomarker expression in different cell subsets. It is ideal for characterizing immune responses in a wide variety of settings, from infection to inflammation and oncology, making it particularly valuable for assessing efficacy of immunomodulatory drugs. The detection of multiple biomarkers expressed by the same cell also makes flow cytometry a versatile tool for drug efficacy testing, since it allows to assess whether a drug not only effectively engages its target, but also induces downstream cell signalling. Further it allows for screening of adverse effects such as off-target binding, oxidative stress, induction of cell death pathways and other signs of toxicity, enhancing drug safety and minimizing costly failures.

Another key application of flow cytometry is immune profiling, which includes the identification and quantification of multiple immune cell subsets within the same specimen. This can be used in a broad variety of settings such as infection, inflammation, autoimmune disease and immuno-oncology and allows to assess how a drug can modulate immune activity in these situations.

Additional applications of flow cytometry include analysis of cell viability and proliferation. By evaluating cell cycle progression and apoptosis, flow cytometry provides valuable insights into how drugs impact cancer cell growth and survival.